Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for CPSF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPSF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPSF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:61,158,562–61,159,021 | 271.2 kb | Distal (>10kb) Multiome | 223 | |
| chr11:61,160,742–61,162,049 | 268.5 kb | Distal (>10kb) Multiome | 851 | |
| chr11:61,281,385–61,282,193 | 148.3 kb | Distal (>10kb) Multiome | 231 | |
| chr11:61,294,197–61,295,784 | 134.8 kb | Distal (>10kb) Multiome | 761 | |
| chr11:61,332,596–61,333,687 | 96.8 kb | Distal (>10kb) Multiome | 897 | |
| chr11:61,361,602–61,362,481 | 67.8 kb | Distal (>10kb) Multiome | 905 | |
| chr11:61,392,209–61,392,929 | 37.4 kb | Distal (>10kb) Multiome | 800 | |
| chr11:61,429,326–61,430,423 | 63 bp | At TSS Multiome | 975 | |
| chr11:61,508,087–61,510,095 | 78.6 kb | Distal (>10kb) Multiome | 740 | |
| chr11:61,567,110–61,568,033 | 137.6 kb | Distal (>10kb) Multiome | 1078 | |
| chr11:61,580,454–61,581,871 | 151.4 kb | Distal (>10kb) Multiome | 760 | |
| chr11:61,587,343–61,588,726 | 158.3 kb | Distal (>10kb) Multiome | 271 | |
| chr11:61,680,168–61,680,631 | 250.4 kb | Distal (>10kb) Multiome | 532 |
Genomic view of the CPSF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.