Predicted to enable RNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in membrane. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CPSF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPSF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPSF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:91,835,675–91,837,066 | 285.4 kb | Distal (>10kb) Multiome | 412 | |
| chr14:91,947,236–91,948,135 | 174.2 kb | Distal (>10kb) Multiome | 316 | |
| chr14:92,039,326–92,040,502 | 81.9 kb | Distal (>10kb) Multiome | 937 | |
| chr14:92,105,904–92,107,104 | 15.3 kb | Distal (>10kb) Multiome | 794 | |
| chr14:92,121,241–92,122,514 | 110 bp | At TSS Multiome | 838 | |
| chr14:92,322,882–92,323,968 | 201.5 kb | Distal (>10kb) Multiome | 231 |
Genomic view of the CPSF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.