The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for CPOX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPOX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPOX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:98,521,861–98,523,430 | 70.7 kb | Distal (>10kb) Multiome | 832 | |
| chr3:98,592,698–98,594,265 | 95 bp | At TSS Multiome | 864 | |
| chr3:98,602,162–98,602,389 | 8.6 kb | Proximal (<10kb) | 163 | |
| chr3:98,732,084–98,734,092 | 138.9 kb | Distal (>10kb) Multiome | 726 | |
| chr3:98,893,597–98,894,718 | 300.4 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the CPOX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.