This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for CPNE7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPNE7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPNE7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:89,290,889–89,291,526 | 284.7 kb | Distal (>10kb) Multiome | 171 | |
| chr16:89,489,154–89,489,850 | 86.4 kb | Distal (>10kb) Multiome | 596 | |
| chr16:89,490,254–89,491,281 | 85.0 kb | Distal (>10kb) Multiome | 817 | |
| chr16:89,507,395–89,509,159 | 67.5 kb | Distal (>10kb) Multiome | 987 | |
| chr16:89,560,298–89,561,204 | 15.1 kb | Distal (>10kb) Multiome | 1030 | |
| chr16:89,564,633–89,566,356 | 10.7 kb | Distal (>10kb) Multiome | 894 | |
| chr16:89,574,359–89,574,949 | 984 bp | At TSS Multiome | 373 | |
| chr16:89,575,067–89,576,317 | at TSS | At TSS | 311 | |
| chr16:89,657,432–89,658,521 | 82.1 kb | Distal (>10kb) Multiome | 859 | |
| chr16:89,686,359–89,687,641 | 111.0 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:89,699,933–89,702,566 | 124.5 kb | Distal (>10kb) Multiome | 1079 | |
| chr16:89,711,278–89,712,334 | 136.0 kb | Distal (>10kb) Multiome | 443 | |
| chr16:89,720,440–89,722,486 | 145.6 kb | Distal (>10kb) Multiome | 1048 | |
| chr16:89,816,022–89,817,100 | 241.0 kb | Distal (>10kb) Multiome | 995 | |
| chr16:89,827,667–89,829,190 | 252.7 kb | Distal (>10kb) Multiome | 784 | |
| chr16:89,872,618–89,874,723 | 298.4 kb | Distal (>10kb) Multiome | 1046 |
Genomic view of the CPNE7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.