Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CPNE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPNE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPNE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:56,861,108–56,861,632 | 231.2 kb | Distal (>10kb) Multiome | 361 | |
| chr16:56,931,455–56,933,141 | 160.5 kb | Distal (>10kb) Multiome | 1047 | |
| chr16:56,989,388–56,989,907 | 103.1 kb | Distal (>10kb) Multiome | 646 | |
| chr16:57,084,316–57,084,538 | 8.1 kb | Proximal (<10kb) | 381 | |
| chr16:57,091,529–57,091,841 | 764 bp | At TSS | 317 | |
| chr16:57,092,097–57,093,443 | 113 bp | At TSS Multiome | 584 | |
| chr16:57,185,577–57,186,853 | 93.6 kb | Distal (>10kb) Multiome | 925 | |
| chr16:57,244,660–57,245,782 | 152.5 kb | Distal (>10kb) Multiome | 949 | |
| chr16:57,256,968–57,257,582 | 164.6 kb | Distal (>10kb) Multiome | 94 | |
| chr16:57,284,181–57,285,057 | 192.1 kb | Distal (>10kb) Multiome | 883 | |
| chr16:57,299,458–57,301,365 | 207.4 kb | Distal (>10kb) Multiome | 1112 |
Genomic view of the CPNE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.