Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CPLX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPLX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPLX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:575,294–576,132 | 250.7 kb | Distal (>10kb) Multiome | 154 | |
| chr4:663,207–664,324 | 162.3 kb | Distal (>10kb) Multiome | 298 | |
| chr4:673,501–675,336 | 151.7 kb | Distal (>10kb) Multiome | 920 | |
| chr4:680,919–681,550 | 144.6 kb | Distal (>10kb) Multiome | 275 | |
| chr4:688,280–689,636 | 136.7 kb | Distal (>10kb) Multiome | 218 | |
| chr4:705,313–706,398 | 120.4 kb | Distal (>10kb) Multiome | 613 | |
| chr4:781,187–782,732 | 44.1 kb | Distal (>10kb) Multiome | 893 | |
| chr4:824,659–825,125 | 1.0 kb | Proximal (<10kb) | 62 | |
| chr4:825,232–826,278 | 9 bp | At TSS Multiome | 317 | |
| chr4:826,462–827,691 | 908 bp | At TSS Multiome | 180 | |
| chr4:931,599–932,710 | 106.3 kb | Distal (>10kb) Multiome | 818 | |
| chr4:972,792–974,408 | 147.5 kb | Distal (>10kb) Multiome | 437 | |
| chr4:986,645–987,589 | 161.0 kb | Distal (>10kb) Multiome | 723 | |
| chr4:1,008,768–1,012,870 | 185.4 kb | Distal (>10kb) Multiome | 793 | |
| chr4:1,113,486–1,113,937 | 287.6 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the CPLX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.