This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for CPAMD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPAMD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPAMD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:16,627,176–16,629,209 | 398.4 kb | Distal (>10kb) Multiome | 896 | |
| chr19:16,659,555–16,661,823 | 366.7 kb | Distal (>10kb) Multiome | 987 | |
| chr19:16,828,911–16,830,011 | 197.4 kb | Distal (>10kb) Multiome | 623 | |
| chr19:16,895,945–16,898,066 | 129.5 kb | Distal (>10kb) Multiome | 632 | |
| chr19:17,026,712–17,027,075 | at TSS | At TSS | 53 | |
| chr19:17,074,934–17,076,532 | 48.8 kb | Distal (>10kb) Multiome | 890 | |
| chr19:17,209,430–17,210,427 | 183.0 kb | Distal (>10kb) Multiome | 245 | |
| chr19:17,215,005–17,215,979 | 188.7 kb | Distal (>10kb) Multiome | 897 | |
| chr19:17,225,705–17,226,889 | 199.6 kb | Distal (>10kb) Multiome | 870 | |
| chr19:17,234,748–17,236,650 | 209.1 kb | Distal (>10kb) Multiome | 612 | |
| chr19:17,244,882–17,247,104 | 219.3 kb | Distal (>10kb) Multiome | 862 | |
| chr19:17,247,935–17,248,860 | 221.8 kb | Distal (>10kb) Multiome | 588 | |
| chr19:17,266,931–17,267,755 | 240.4 kb | Distal (>10kb) Multiome | 720 | |
| chr19:17,281,537–17,283,120 | 256.0 kb | Distal (>10kb) Multiome | 669 | |
| chr19:17,292,242–17,293,049 | 265.9 kb | Distal (>10kb) Multiome | 513 | |
| chr19:17,302,721–17,303,771 | 276.6 kb | Distal (>10kb) Multiome | 636 | |
| chr19:17,305,286–17,306,514 | 278.9 kb | Distal (>10kb) Multiome | 947 | |
| chr19:17,309,159–17,310,151 | 282.7 kb | Distal (>10kb) Multiome | 741 |
Genomic view of the CPAMD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.