The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for CP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:148,991,054–148,992,463 | 206.9 kb | Distal (>10kb) Multiome | 826 | |
| chr3:149,085,604–149,087,032 | 111.9 kb | Distal (>10kb) Multiome | 1012 | |
| chr3:149,129,236–149,130,370 | 68.8 kb | Distal (>10kb) Multiome | 951 | |
| chr3:149,196,583–149,197,308 | 1.5 kb | Proximal (<10kb) Multiome | 127 | |
| chr3:149,197,375–149,197,971 | 481 bp | At TSS | 99 | |
| chr3:149,198,425–149,199,153 | 344 bp | At TSS Multiome | 164 | |
| chr3:149,352,512–149,352,988 | 154.3 kb | Distal (>10kb) Multiome | 387 |
Genomic view of the CP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.