The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COX8A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX8A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX8A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,680,920–63,682,270 | 293.1 kb | Distal (>10kb) Multiome | 869 | |
| chr11:63,761,764–63,765,204 | 210.5 kb | Distal (>10kb) Multiome | 463 | |
| chr11:63,767,471–63,769,982 | 207.0 kb | Distal (>10kb) Multiome | 627 | |
| chr11:63,813,022–63,814,238 | 161.2 kb | Distal (>10kb) Multiome | 704 | |
| chr11:63,838,214–63,839,799 | 135.7 kb | Distal (>10kb) Multiome | 687 | |
| chr11:63,888,171–63,888,861 | 86.1 kb | Distal (>10kb) Multiome | 565 | |
| chr11:63,909,610–63,910,221 | 64.6 kb | Distal (>10kb) Multiome | 113 | |
| chr11:63,916,069–63,921,372 | 55.1 kb | Distal (>10kb) Multiome | 929 | |
| chr11:63,938,087–63,939,846 | 35.8 kb | Distal (>10kb) Multiome | 852 | |
| chr11:63,974,156–63,975,123 | 93 bp | At TSS Multiome | 918 | |
| chr11:63,986,198–63,987,213 | 11.9 kb | Distal (>10kb) Multiome | 895 | |
| chr11:63,998,533–64,001,109 | 24.8 kb | Distal (>10kb) Multiome | 414 | |
| chr11:64,028,126–64,028,898 | 54.0 kb | Distal (>10kb) Multiome | 168 | |
| chr11:64,165,638–64,166,698 | 191.6 kb | Distal (>10kb) Multiome | 811 | |
| chr11:64,184,927–64,186,817 | 211.3 kb | Distal (>10kb) Multiome | 1091 | |
| chr11:64,225,548–64,226,862 | 251.6 kb | Distal (>10kb) Multiome | 776 | |
| chr11:64,230,074–64,231,130 | 255.9 kb | Distal (>10kb) Multiome | 715 | |
| chr11:64,233,950–64,235,296 | 259.9 kb | Distal (>10kb) Multiome | 590 | |
| chr11:64,240,398–64,242,687 | 266.7 kb | Distal (>10kb) Multiome | 982 | |
| chr11:64,246,274–64,248,065 | 272.5 kb | Distal (>10kb) Multiome | 802 | |
| chr11:64,250,699–64,251,842 | 276.8 kb | Distal (>10kb) Multiome | 498 | |
| chr11:64,268,509–64,270,920 | 295.5 kb | Distal (>10kb) Multiome | 1093 | |
| chr11:64,271,352–64,271,994 | 297.0 kb | Distal (>10kb) Multiome | 595 |
Genomic view of the COX8A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.