Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for COX7A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX7A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX7A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:73,653,023–73,654,818 | 1589.8 kb | Distal (>10kb) Multiome HiCAR | 944 | |
| chr6:73,695,662–73,696,526 | 1547.7 kb | Distal (>10kb) Multiome HiCAR | 534 | |
| chr6:75,204,283–75,209,417 | 37.7 kb | Distal (>10kb) Multiome | 741 | |
| chr6:75,243,188–75,244,541 | 22 bp | At TSS Multiome | 858 | |
| chr6:75,250,688–75,251,084 | 6.9 kb | Proximal (<10kb) | 11 | |
| chr6:75,283,886–75,285,703 | 41.1 kb | Distal (>10kb) Multiome | 948 | |
| chr6:75,334,164–75,335,181 | 91.0 kb | Distal (>10kb) Multiome | 265 | |
| chr6:75,348,793–75,350,207 | 105.7 kb | Distal (>10kb) Multiome | 378 | |
| chr6:75,396,170–75,397,131 | 152.8 kb | Distal (>10kb) Multiome | 169 |
Genomic view of the COX7A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.