This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for COX14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:49,827,122–49,829,288 | 283.6 kb | Distal (>10kb) Multiome | 839 | |
| chr12:49,842,401–49,843,296 | 269.1 kb | Distal (>10kb) Multiome | 806 | |
| chr12:49,866,994–49,867,580 | 244.8 kb | Distal (>10kb) Multiome | 334 | |
| chr12:49,945,408–49,945,886 | 166.4 kb | Distal (>10kb) Multiome | 520 | |
| chr12:49,961,271–49,962,190 | 150.4 kb | Distal (>10kb) Multiome | 164 | |
| chr12:49,966,854–49,967,924 | 144.7 kb | Distal (>10kb) Multiome | 698 | |
| chr12:50,024,956–50,025,990 | 86.5 kb | Distal (>10kb) Multiome | 829 | |
| chr12:50,050,458–50,051,443 | 61.2 kb | Distal (>10kb) Multiome | 412 | |
| chr12:50,057,263–50,058,231 | 54.4 kb | Distal (>10kb) Multiome | 437 | |
| chr12:50,084,798–50,085,859 | 26.8 kb | Distal (>10kb) Multiome | 715 | |
| chr12:50,110,765–50,112,744 | 121 bp | At TSS Multiome | 967 | |
| chr12:50,166,692–50,167,931 | 55.4 kb | Distal (>10kb) Multiome HiCAR | 812 | |
| chr12:50,232,842–50,233,291 | 121.0 kb | Distal (>10kb) Multiome | 105 | |
| chr12:50,283,141–50,284,081 | 171.5 kb | Distal (>10kb) Multiome | 750 | |
| chr12:50,400,518–50,401,658 | 288.8 kb | Distal (>10kb) Multiome | 948 |
Genomic view of the COX14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.