This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COQ8A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COQ8A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COQ8A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:226,679,874–226,680,709 | 260.1 kb | Distal (>10kb) Multiome | 422 | |
| chr1:226,736,695–226,739,072 | 202.9 kb | Distal (>10kb) Multiome | 426 | |
| chr1:226,824,867–226,826,112 | 115.0 kb | Distal (>10kb) Multiome | 167 | |
| chr1:226,827,950–226,828,394 | 112.1 kb | Distal (>10kb) Multiome | 514 | |
| chr1:226,870,257–226,871,262 | 69.6 kb | Distal (>10kb) Multiome | 692 | |
| chr1:226,939,374–226,940,917 | 168 bp | At TSS Multiome | 1091 | |
| chr1:226,944,823–226,946,056 | 5.3 kb | Proximal (<10kb) Multiome | 574 |
Genomic view of the COQ8A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.