The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for COQ7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COQ7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COQ7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:18,789,852–18,790,674 | 277.2 kb | Distal (>10kb) Multiome | 1043 | |
| chr16:18,800,801–18,802,152 | 265.9 kb | Distal (>10kb) Multiome | 1139 | |
| chr16:18,925,547–18,927,198 | 141.1 kb | Distal (>10kb) Multiome | 788 | |
| chr16:18,983,732–18,984,444 | 83.6 kb | Distal (>10kb) Multiome | 817 | |
| chr16:19,067,380–19,068,213 | 73 bp | At TSS Multiome | 982 | |
| chr16:19,086,334–19,086,896 | 19.0 kb | Distal (>10kb) Multiome | 852 | |
| chr16:19,113,633–19,114,626 | 46.4 kb | Distal (>10kb) Multiome | 801 | |
| chr16:19,167,649–19,168,727 | 100.3 kb | Distal (>10kb) Multiome | 572 | |
| chr16:19,299,373–19,300,029 | 232.1 kb | Distal (>10kb) Multiome | 136 | |
| chr16:19,348,618–19,349,340 | 281.4 kb | Distal (>10kb) Multiome | 189 |
Genomic view of the COQ7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.