The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COPS8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPS8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPS8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:236,177,631–236,178,437 | 907.8 kb | Distal (>10kb) Multiome HiCAR | 437 | |
| chr2:236,237,432–236,238,127 | 848.2 kb | Distal (>10kb) Multiome HiCAR | 130 | |
| chr2:236,567,303–236,570,807 | 518.2 kb | Distal (>10kb) Multiome HiCAR | 479 | |
| chr2:236,822,898–236,824,383 | 262.6 kb | Distal (>10kb) Multiome | 178 | |
| chr2:236,955,589–236,957,065 | 129.5 kb | Distal (>10kb) Multiome | 297 | |
| chr2:237,085,238–237,086,212 | 129 bp | At TSS Multiome | 935 | |
| chr2:237,134,316–237,134,940 | 48.6 kb | Distal (>10kb) Multiome | 94 |
Genomic view of the COPS8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.