This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for COPS7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPS7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPS7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,451,305–6,451,838 | 272.6 kb | Distal (>10kb) Multiome | 535 | |
| chr12:6,469,922–6,471,399 | 253.2 kb | Distal (>10kb) Multiome | 930 | |
| chr12:6,492,998–6,494,331 | 230.7 kb | Distal (>10kb) Multiome | 936 | |
| chr12:6,533,253–6,535,726 | 189.7 kb | Distal (>10kb) Multiome | 1131 | |
| chr12:6,539,914–6,540,883 | 183.4 kb | Distal (>10kb) Multiome | 427 | |
| chr12:6,554,111–6,554,621 | 169.7 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,555,532–6,556,318 | 168.0 kb | Distal (>10kb) Multiome | 551 | |
| chr12:6,567,822–6,568,719 | 155.7 kb | Distal (>10kb) Multiome | 837 | |
| chr12:6,605,947–6,607,790 | 116.6 kb | Distal (>10kb) Multiome | 774 | |
| chr12:6,613,155–6,614,551 | 109.9 kb | Distal (>10kb) Multiome | 810 | |
| chr12:6,620,128–6,620,868 | 103.5 kb | Distal (>10kb) Multiome | 239 | |
| chr12:6,662,802–6,663,663 | 60.8 kb | Distal (>10kb) Multiome | 868 | |
| chr12:6,688,517–6,690,027 | 34.6 kb | Distal (>10kb) Multiome | 943 | |
| chr12:6,699,959–6,700,887 | 23.6 kb | Distal (>10kb) Multiome | 263 | |
| chr12:6,720,678–6,721,033 | 3.0 kb | Proximal (<10kb) | 40 | |
| chr12:6,723,658–6,724,773 | 52 bp | At TSS Multiome | 1065 | |
| chr12:6,752,554–6,754,332 | 29.4 kb | Distal (>10kb) Multiome | 975 | |
| chr12:6,763,677–6,764,983 | 40.3 kb | Distal (>10kb) Multiome | 570 | |
| chr12:6,765,172–6,767,791 | 42.3 kb | Distal (>10kb) Multiome | 824 | |
| chr12:6,768,329–6,769,331 | 45.1 kb | Distal (>10kb) Multiome | 249 | |
| chr12:6,778,736–6,779,459 | 55.0 kb | Distal (>10kb) Multiome | 777 | |
| chr12:6,821,268–6,822,155 | 97.7 kb | Distal (>10kb) Multiome | 299 | |
| chr12:6,825,458–6,825,915 | 101.7 kb | Distal (>10kb) Multiome | 404 | |
| chr12:6,828,101–6,829,966 | 105.5 kb | Distal (>10kb) Multiome | 689 | |
| chr12:6,851,017–6,853,279 | 128.3 kb | Distal (>10kb) Multiome | 966 | |
| chr12:6,866,801–6,870,175 | 143.5 kb | Distal (>10kb) Multiome | 887 | |
| chr12:6,871,062–6,874,199 | 148.3 kb | Distal (>10kb) Multiome | 947 | |
| chr12:6,890,735–6,891,820 | 167.2 kb | Distal (>10kb) Multiome | 908 | |
| chr12:6,904,217–6,905,282 | 180.8 kb | Distal (>10kb) Multiome | 566 | |
| chr12:6,914,274–6,914,898 | 190.4 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,924,156–6,924,592 | 200.4 kb | Distal (>10kb) Multiome | 458 | |
| chr12:6,925,828–6,926,431 | 201.9 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,927,411–6,928,051 | 203.8 kb | Distal (>10kb) Multiome | 493 | |
| chr12:6,936,709–6,938,342 | 214.0 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:6,942,356–6,945,492 | 220.2 kb | Distal (>10kb) Multiome | 1205 | |
| chr12:6,945,587–6,947,099 | 222.4 kb | Distal (>10kb) Multiome | 618 | |
| chr12:6,961,769–6,963,542 | 239.1 kb | Distal (>10kb) Multiome | 682 | |
| chr12:6,964,932–6,965,569 | 241.2 kb | Distal (>10kb) Multiome | 549 | |
| chr12:6,970,111–6,971,189 | 246.7 kb | Distal (>10kb) Multiome | 899 | |
| chr12:7,018,028–7,019,126 | 294.7 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the COPS7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.