Predicted to enable transcription corepressor activity. Involved in protein deneddylation and protein phosphorylation. Located in cytoplasm and nucleus. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COPS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:48,877,739–48,878,642 | 277.4 kb | Distal (>10kb) Multiome | 662 | |
| chr15:48,962,833–48,964,051 | 192.0 kb | Distal (>10kb) Multiome | 430 | |
| chr15:48,975,511–48,976,786 | 179.6 kb | Distal (>10kb) Multiome | 622 | |
| chr15:49,045,768–49,047,113 | 109.1 kb | Distal (>10kb) Multiome | 979 | |
| chr15:49,154,953–49,156,105 | 94 bp | At TSS Multiome | 952 | |
| chr15:49,169,904–49,170,701 | 14.6 kb | Distal (>10kb) Multiome | 762 | |
| chr15:49,225,493–49,226,165 | 70.2 kb | Distal (>10kb) Multiome | 183 | |
| chr15:50,907,855–50,909,463 | 1753.0 kb | Distal (>10kb) Multiome HiCAR | 953 |
Genomic view of the COPS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.