Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in methylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COMTD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COMTD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COMTD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:75,043,531–75,044,056 | 192.2 kb | Distal (>10kb) Multiome | 156 | |
| chr10:75,058,930–75,059,944 | 176.4 kb | Distal (>10kb) Multiome | 137 | |
| chr10:75,079,403–75,080,508 | 156.1 kb | Distal (>10kb) Multiome | 189 | |
| chr10:75,099,885–75,100,763 | 135.8 kb | Distal (>10kb) Multiome | 419 | |
| chr10:75,111,043–75,112,358 | 124.4 kb | Distal (>10kb) Multiome HiCAR | 857 | |
| chr10:75,188,012–75,188,453 | 47.7 kb | Distal (>10kb) Multiome | 268 | |
| chr10:75,206,644–75,207,978 | 28.5 kb | Distal (>10kb) Multiome | 207 | |
| chr10:75,209,910–75,211,260 | 25.4 kb | Distal (>10kb) Multiome | 1059 | |
| chr10:75,230,656–75,230,874 | 5.1 kb | Proximal (<10kb) | 269 | |
| chr10:75,233,116–75,236,429 | 115 bp | At TSS Multiome | 1015 | |
| chr10:75,294,540–75,295,659 | 59.2 kb | Distal (>10kb) Multiome | 702 | |
| chr10:75,395,145–75,397,482 | 161.3 kb | Distal (>10kb) Multiome | 341 | |
| chr10:75,398,678–75,400,431 | 164.0 kb | Distal (>10kb) Multiome | 501 | |
| chr10:75,400,704–75,404,045 | 166.2 kb | Distal (>10kb) Multiome | 978 | |
| chr10:75,404,151–75,405,735 | 169.2 kb | Distal (>10kb) Multiome | 760 | |
| chr10:75,408,986–75,410,039 | 173.5 kb | Distal (>10kb) Multiome | 639 | |
| chr10:75,417,113–75,418,105 | 181.8 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the COMTD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.