Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COMMD10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COMMD10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COMMD10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:115,785,567–115,786,155 | 299.2 kb | Distal (>10kb) Multiome | 90 | |
| chr5:115,815,539–115,817,207 | 268.4 kb | Distal (>10kb) Multiome | 490 | |
| chr5:115,840,887–115,842,729 | 243.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr5:116,084,169–116,085,557 | 128 bp | At TSS Multiome | 922 | |
| chr5:116,343,834–116,344,383 | 259.1 kb | Distal (>10kb) Multiome | 101 | |
| chr5:116,361,097–116,362,155 | 276.6 kb | Distal (>10kb) Multiome | 208 |
Genomic view of the COMMD10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.