This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for COL14A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COL14A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COL14A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:119,832,338–119,833,429 | 292.3 kb | Distal (>10kb) Multiome | 811 | |
| chr8:119,855,284–119,857,254 | 269.2 kb | Distal (>10kb) Multiome | 941 | |
| chr8:119,873,210–119,874,965 | 251.4 kb | Distal (>10kb) Multiome | 871 | |
| chr8:120,047,941–120,048,921 | 76.9 kb | Distal (>10kb) Multiome | 198 | |
| chr8:120,120,995–120,121,496 | 3.6 kb | Proximal (<10kb) | 8 | |
| chr8:120,123,318–120,126,661 | 1.4 kb | Proximal (<10kb) Multiome | 769 | |
| chr8:120,127,732–120,127,944 | 2.6 kb | Proximal (<10kb) | 47 | |
| chr8:120,444,671–120,445,755 | 320.2 kb | Distal (>10kb) Multiome HiCAR | 861 |
Genomic view of the COL14A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.