The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for COG7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COG7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COG7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:23,182,254–23,183,374 | 270.6 kb | Distal (>10kb) Multiome HiCAR | 606 | |
| chr16:23,452,612–23,453,515 | 190 bp | At TSS Multiome | 1008 | |
| chr16:23,509,880–23,510,853 | 57.3 kb | Distal (>10kb) Multiome | 947 | |
| chr16:23,557,038–23,558,356 | 104.3 kb | Distal (>10kb) Multiome | 1119 | |
| chr16:23,595,873–23,596,693 | 143.1 kb | Distal (>10kb) Multiome | 938 | |
| chr16:23,640,088–23,640,480 | 187.0 kb | Distal (>10kb) Multiome | 169 | |
| chr16:23,641,019–23,641,779 | 188.2 kb | Distal (>10kb) Multiome | 1055 | |
| chr16:23,678,415–23,679,119 | 225.6 kb | Distal (>10kb) Multiome | 878 | |
| chr16:23,694,678–23,695,256 | 241.8 kb | Distal (>10kb) Multiome | 456 |
Genomic view of the COG7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.