The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for COG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:107,405,077–107,405,978 | 158.5 kb | Distal (>10kb) Multiome | 209 | |
| chr7:107,563,398–107,564,589 | 35 bp | At TSS Multiome | 912 | |
| chr7:107,579,664–107,580,832 | 16.3 kb | Distal (>10kb) Multiome | 915 | |
| chr7:107,660,462–107,662,091 | 97.6 kb | Distal (>10kb) Multiome | 578 | |
| chr7:107,742,953–107,744,685 | 179.9 kb | Distal (>10kb) Multiome | 1055 |
Genomic view of the COG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.