This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. Mutations in this gene are associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to a severe disease affecting several tissues and organs. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for COA5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COA5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COA5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:98,346,371–98,347,129 | 261.9 kb | Distal (>10kb) Multiome | 241 | |
| chr2:98,357,468–98,358,266 | 250.5 kb | Distal (>10kb) Multiome | 122 | |
| chr2:98,444,269–98,445,711 | 163.7 kb | Distal (>10kb) Multiome | 701 | |
| chr2:98,466,263–98,466,729 | 142.0 kb | Distal (>10kb) Multiome | 102 | |
| chr2:98,494,179–98,495,859 | 113.6 kb | Distal (>10kb) Multiome | 218 | |
| chr2:98,513,976–98,514,722 | 94.1 kb | Distal (>10kb) Multiome | 137 | |
| chr2:98,601,618–98,601,863 | 6.6 kb | Proximal (<10kb) | 182 | |
| chr2:98,602,818–98,603,285 | 5.2 kb | Proximal (<10kb) | 74 | |
| chr2:98,608,079–98,608,886 | 19 bp | At TSS Multiome | 1004 | |
| chr2:98,610,577–98,611,043 | 2.1 kb | Proximal (<10kb) | 7 | |
| chr2:98,611,155–98,612,164 | 3.0 kb | Proximal (<10kb) Multiome | 120 | |
| chr2:98,730,234–98,731,725 | 122.6 kb | Distal (>10kb) Multiome | 720 | |
| chr2:98,822,458–98,823,460 | 214.3 kb | Distal (>10kb) Multiome | 209 |
Genomic view of the COA5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.