Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:73,597,688–73,598,911 | 278.5 kb | Distal (>10kb) Multiome | 887 | |
| chr11:73,645,683–73,646,788 | 230.6 kb | Distal (>10kb) Multiome | 193 | |
| chr11:73,647,445–73,647,968 | 229.2 kb | Distal (>10kb) Multiome | 442 | |
| chr11:73,660,644–73,661,627 | 215.6 kb | Distal (>10kb) Multiome | 525 | |
| chr11:73,760,242–73,761,712 | 115.6 kb | Distal (>10kb) Multiome | 842 | |
| chr11:73,779,162–73,780,136 | 97.2 kb | Distal (>10kb) Multiome | 920 | |
| chr11:73,787,771–73,788,337 | 88.7 kb | Distal (>10kb) Multiome | 1000 | |
| chr11:73,876,432–73,877,378 | 56 bp | At TSS Multiome | 911 | |
| chr11:73,982,330–73,983,905 | 106.3 kb | Distal (>10kb) Multiome | 1122 | |
| chr11:74,170,498–74,171,610 | 294.3 kb | Distal (>10kb) Multiome | 881 |
Genomic view of the COA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.