Involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respiratory chain complex I assembly. Located in cytosol and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:43,439,357–43,440,269 | 289.7 kb | Distal (>10kb) Multiome | 289 | |
| chr7:43,582,521–43,583,972 | 146.5 kb | Distal (>10kb) Multiome | 861 | |
| chr7:43,729,165–43,729,933 | 63 bp | At TSS Multiome | 896 | |
| chr7:43,758,058–43,759,333 | 29.3 kb | Distal (>10kb) Multiome | 665 | |
| chr7:43,838,582–43,839,204 | 109.5 kb | Distal (>10kb) Multiome | 647 | |
| chr7:43,868,905–43,870,110 | 140.0 kb | Distal (>10kb) Multiome | 804 | |
| chr7:43,905,962–43,907,078 | 177.1 kb | Distal (>10kb) Multiome | 557 | |
| chr7:43,926,113–43,927,072 | 197.0 kb | Distal (>10kb) Multiome | 1004 | |
| chr7:43,985,975–43,986,501 | 256.8 kb | Distal (>10kb) Multiome | 113 | |
| chr7:44,018,938–44,019,667 | 289.7 kb | Distal (>10kb) Multiome | 564 |
Genomic view of the COA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.