Predicted to enable 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Located in cytoplasm; extracellular space; and microtubule. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CNP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:41,665,564–41,667,291 | 299.5 kb | Distal (>10kb) Multiome | 883 | |
| chr17:41,688,103–41,690,064 | 277.9 kb | Distal (>10kb) Multiome | 1236 | |
| chr17:41,733,761–41,735,187 | 232.0 kb | Distal (>10kb) Multiome | 577 | |
| chr17:41,738,054–41,738,690 | 228.5 kb | Distal (>10kb) Multiome | 596 | |
| chr17:41,784,980–41,787,229 | 179.9 kb | Distal (>10kb) Multiome | 958 | |
| chr17:41,793,527–41,794,326 | 172.9 kb | Distal (>10kb) Multiome | 597 | |
| chr17:41,800,647–41,802,040 | 164.8 kb | Distal (>10kb) Multiome | 766 | |
| chr17:41,811,252–41,813,275 | 153.8 kb | Distal (>10kb) Multiome | 997 | |
| chr17:41,835,756–41,836,400 | 130.6 kb | Distal (>10kb) Multiome | 568 | |
| chr17:41,864,608–41,865,695 | 101.3 kb | Distal (>10kb) Multiome | 913 | |
| chr17:41,913,670–41,914,569 | 52.7 kb | Distal (>10kb) Multiome | 190 | |
| chr17:41,918,026–41,919,794 | 47.6 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 36.2 kb | Distal (>10kb) Multiome | 915 | |
| chr17:41,959,773–41,959,970 | 6.8 kb | Proximal (<10kb) | 387 | |
| chr17:41,963,045–41,963,258 | 3.5 kb | Proximal (<10kb) | 318 | |
| chr17:41,965,771–41,967,327 | 11 bp | At TSS Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 50.7 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 53.3 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 83.8 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 141.1 kb | Distal (>10kb) Multiome HiCAR | 357 | |
| chr17:42,120,858–42,121,715 | 154.5 kb | Distal (>10kb) Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 155.9 kb | Distal (>10kb) Multiome | 169 | |
| chr17:42,154,717–42,156,309 | 188.4 kb | Distal (>10kb) Multiome | 770 | |
| chr17:42,180,242–42,180,762 | 213.6 kb | Distal (>10kb) Multiome | 576 | |
| chr17:42,183,755–42,184,761 | 217.5 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the CNP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.