This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for CNNM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNNM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNNM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,641,824–102,646,130 | 273.2 kb | Distal (>10kb) Multiome | 1123 | |
| chr10:102,678,809–102,679,295 | 239.3 kb | Distal (>10kb) Multiome | 476 | |
| chr10:102,713,669–102,715,337 | 203.9 kb | Distal (>10kb) Multiome | 895 | |
| chr10:102,743,388–102,744,547 | 174.5 kb | Distal (>10kb) Multiome | 777 | |
| chr10:102,776,775–102,777,340 | 141.3 kb | Distal (>10kb) Multiome | 419 | |
| chr10:102,853,920–102,854,718 | 63.9 kb | Distal (>10kb) Multiome | 859 | |
| chr10:102,869,308–102,870,223 | 48.8 kb | Distal (>10kb) Multiome | 509 | |
| chr10:102,916,941–102,919,907 | 147 bp | At TSS Multiome | 984 | |
| chr10:103,192,518–103,193,861 | 274.9 kb | Distal (>10kb) Multiome | 725 | |
| chr10:103,204,930–103,206,025 | 286.8 kb | Distal (>10kb) Multiome | 207 | |
| chr10:103,206,729–103,207,578 | 288.9 kb | Distal (>10kb) Multiome | 46 |
Genomic view of the CNNM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.