This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for CMTM8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMTM8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMTM8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:31,960,050–31,961,036 | 278.2 kb | Distal (>10kb) Multiome | 187 | |
| chr3:31,980,333–31,982,170 | 257.2 kb | Distal (>10kb) Multiome | 808 | |
| chr3:32,105,961–32,107,302 | 132.2 kb | Distal (>10kb) Multiome | 774 | |
| chr3:32,237,938–32,239,504 | 10 bp | At TSS Multiome | 757 | |
| chr3:32,240,180–32,240,364 | 1.5 kb | Proximal (<10kb) | 135 | |
| chr3:32,391,537–32,392,862 | 153.2 kb | Distal (>10kb) Multiome | 743 | |
| chr3:32,401,271–32,402,070 | 163.1 kb | Distal (>10kb) Multiome | 697 | |
| chr3:32,410,258–32,411,225 | 172.2 kb | Distal (>10kb) Multiome | 187 | |
| chr3:32,459,983–32,460,759 | 221.6 kb | Distal (>10kb) Multiome | 287 | |
| chr3:32,467,571–32,468,117 | 229.2 kb | Distal (>10kb) Multiome | 389 | |
| chr3:32,502,116–32,503,121 | 264.0 kb | Distal (>10kb) Multiome | 723 |
Genomic view of the CMTM8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.