This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CMIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:81,180,983–81,181,563 | 263.4 kb | Distal (>10kb) Multiome | 479 | |
| chr16:81,314,548–81,315,884 | 129.9 kb | Distal (>10kb) Multiome | 933 | |
| chr16:81,403,561–81,404,209 | 41.0 kb | Distal (>10kb) Multiome | 694 | |
| chr16:81,443,946–81,445,799 | 115 bp | At TSS Multiome | 618 | |
| chr16:81,447,553–81,447,965 | 2.7 kb | Proximal (<10kb) | 319 | |
| chr16:81,558,602–81,559,161 | 114.2 kb | Distal (>10kb) Multiome | 376 | |
| chr16:81,634,541–81,635,252 | 190.1 kb | Distal (>10kb) Multiome | 306 | |
| chr16:81,729,445–81,731,113 | 285.7 kb | Distal (>10kb) Multiome | 754 | |
| chr16:81,737,865–81,738,303 | 293.3 kb | Distal (>10kb) Multiome | 489 |
Genomic view of the CMIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.