This gene encodes a protein that belongs to the SEC14/CRAL-TRIO family of proteins. A similar protein in rat is thought to function in the endosomal pathway between early endosomes and mature lysosomes. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for CLVS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLVS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLVS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:122,788,744–122,791,248 | 206.7 kb | Distal (>10kb) Multiome | 1097 | |
| chr6:122,994,138–122,994,815 | 1.7 kb | Proximal (<10kb) Multiome | 128 | |
| chr6:122,995,717–122,998,127 | 51 bp | At TSS Multiome | 470 | |
| chr6:123,001,402–123,001,855 | 5.2 kb | Proximal (<10kb) | 66 | |
| chr6:123,044,133–123,046,093 | 48.5 kb | Distal (>10kb) Multiome | 252 |
Genomic view of the CLVS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.