The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for CLUAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLUAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLUAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:3,182,514–3,183,488 | 318.1 kb | Distal (>10kb) Multiome HiCAR | 690 | |
| chr16:3,187,874–3,189,822 | 311.5 kb | Distal (>10kb) Multiome HiCAR | 679 | |
| chr16:3,234,780–3,235,610 | 265.8 kb | Distal (>10kb) Multiome | 845 | |
| chr16:3,263,988–3,264,941 | 236.5 kb | Distal (>10kb) Multiome | 923 | |
| chr16:3,282,413–3,283,892 | 217.9 kb | Distal (>10kb) Multiome | 964 | |
| chr16:3,305,073–3,306,009 | 195.5 kb | Distal (>10kb) Multiome | 681 | |
| chr16:3,400,631–3,401,665 | 99.9 kb | Distal (>10kb) Multiome | 927 | |
| chr16:3,457,535–3,458,643 | 43.1 kb | Distal (>10kb) Multiome | 954 | |
| chr16:3,500,701–3,501,337 | 30 bp | At TSS Multiome | 953 | |
| chr16:3,610,900–3,612,357 | 110.6 kb | Distal (>10kb) Multiome | 733 | |
| chr16:3,654,171–3,654,861 | 153.5 kb | Distal (>10kb) Multiome | 445 | |
| chr16:3,716,849–3,718,043 | 216.6 kb | Distal (>10kb) Multiome | 839 |
Genomic view of the CLUAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.