CLU

CLU

clusterin | CLU1, CLU2, KUB1, SGP-2, SP-40, TRPM-2, APOJ, CLI

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

Developmental clusters: GC5

Biological processes 111 terms

ATP hydrolysis activity (GO:0016887)Golgi apparatus (GO:0005794)amyloid-beta binding (GO:0001540)amyloid-beta binding (GO:0001540)amyloid-beta clearance (GO:0097242)apical dendrite (GO:0097440)blood microparticle (GO:0072562)cell morphogenesis (GO:0000902)cell periphery (GO:0071944)cell surface (GO:0009986)central nervous system myelin maintenance (GO:0032286)chaperone-mediated protein complex assembly (GO:0051131)chromaffin granule (GO:0042583)complement activation (GO:0006956)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)immune complex clearance (GO:0002434)immune complex clearance (GO:0002434)intracellular membrane-bounded organelle (GO:0043231)intrinsic apoptotic signaling pathway (GO:0097193)lipid metabolic process (GO:0006629)low-density lipoprotein particle receptor binding (GO:0050750)membrane (GO:0016020)microglial cell activation (GO:0001774)microglial cell proliferation (GO:0061518)misfolded protein binding (GO:0051787)misfolded protein binding (GO:0051787)misfolded protein binding (GO:0051787)mitochondrial inner membrane (GO:0005743)mitochondrial membrane (GO:0031966)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of activation of membrane attack complex (GO:0001971)negative regulation of amyloid fibril formation (GO:1905907)negative regulation of amyloid fibril formation (GO:1905907)negative regulation of amyloid fibril formation (GO:1905907)negative regulation of amyloid-beta formation (GO:1902430)negative regulation of complement activation (GO:0045916)negative regulation of complement-dependent cytotoxicity (GO:1903660)negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)negative regulation of neuron apoptotic process (GO:0043524)negative regulation of protein-containing complex assembly (GO:0031333)negative regulation of protein-containing complex assembly (GO:0031333)negative regulation of release of cytochrome c from mitochondria (GO:0090201)negative regulation of response to endoplasmic reticulum stress (GO:1903573)neurofibrillary tangle (GO:0097418)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear endoplasmic reticulum lumen (GO:0099020)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)platelet alpha granule lumen (GO:0031093)positive regulation of amyloid fibril formation (GO:1905908)positive regulation of amyloid-beta formation (GO:1902004)positive regulation of amyloid-beta formation (GO:1902004)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of gene expression (GO:0010628)positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)positive regulation of neurofibrillary tangle assembly (GO:1902998)positive regulation of nitric oxide biosynthetic process (GO:0045429)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of protein-containing complex assembly (GO:0031334)positive regulation of receptor-mediated endocytosis (GO:0048260)positive regulation of receptor-mediated endocytosis (GO:0048260)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of ubiquitin-dependent protein catabolic process (GO:2000060)protein binding (GO:0005515)protein carrier activity (GO:0140597)protein folding (GO:0006457)protein heterodimerization activity (GO:0046982)protein import (GO:0017038)protein sequestering activity (GO:0140311)protein stabilization (GO:0050821)protein targeting to lysosome involved in chaperone-mediated autophagy (GO:0061740)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)protein-folding chaperone binding (GO:0051087)receptor ligand activity (GO:0048018)regulation of amyloid-beta clearance (GO:1900221)regulation of apoptotic process (GO:0042981)regulation of cell population proliferation (GO:0042127)regulation of neuronal signal transduction (GO:1902847)release of cytochrome c from mitochondria (GO:0001836)response to misfolded protein (GO:0051788)response to virus (GO:0009615)reverse cholesterol transport (GO:0043691)signaling receptor binding (GO:0005102)spherical high-density lipoprotein particle (GO:0034366)synapse (GO:0045202)tau protein binding (GO:0048156)ubiquitin protein ligase binding (GO:0031625)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating CLU 0 TFs

Transcription factors with Perturb-seq knockdown data for CLU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CLU

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr8:27,490,586–27,491,648	123.6 kb	Distal (>10kb) Multiome	837
	chr8:27,592,228–27,592,758	22.2 kb	Distal (>10kb) Multiome	524
	chr8:27,608,493–27,608,956	5.9 kb	Proximal (<10kb) Multiome	168
	chr8:27,614,194–27,615,207	88 bp	At TSS Multiome	844
	chr8:27,633,626–27,634,225	19.2 kb	Distal (>10kb) Multiome	300
	chr8:27,729,944–27,730,631	115.6 kb	Distal (>10kb) Multiome HiCAR	159
	chr8:27,772,146–27,773,026	157.9 kb	Distal (>10kb) Multiome HiCAR	823
	chr8:27,774,174–27,774,993	159.8 kb	Distal (>10kb) Multiome HiCAR	712
	chr8:27,837,400–27,838,016	223.1 kb	Distal (>10kb) Multiome	867

Genome Browser

Genomic view of the CLU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.