This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CLEC11A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLEC11A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLEC11A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,431,430–50,432,503 | 291.5 kb | Distal (>10kb) Multiome | 530 | |
| chr19:50,475,914–50,477,044 | 246.8 kb | Distal (>10kb) Multiome | 622 | |
| chr19:50,510,707–50,511,948 | 212.0 kb | Distal (>10kb) Multiome | 794 | |
| chr19:50,556,266–50,557,084 | 166.7 kb | Distal (>10kb) Multiome | 463 | |
| chr19:50,639,246–50,640,210 | 83.7 kb | Distal (>10kb) Multiome | 326 | |
| chr19:50,657,814–50,659,557 | 65.1 kb | Distal (>10kb) Multiome | 790 | |
| chr19:50,722,999–50,723,615 | at TSS | At TSS | 140 | |
| chr19:50,723,765–50,725,772 | 1.6 kb | Proximal (<10kb) Multiome | 721 | |
| chr19:50,728,202–50,728,738 | 5.2 kb | Proximal (<10kb) Multiome | 345 | |
| chr19:50,804,189–50,805,375 | 81.6 kb | Distal (>10kb) Multiome | 919 | |
| chr19:50,835,543–50,836,598 | 112.7 kb | Distal (>10kb) Multiome | 561 | |
| chr19:50,909,047–50,910,046 | 186.2 kb | Distal (>10kb) Multiome | 239 | |
| chr19:50,921,645–50,922,754 | 198.9 kb | Distal (>10kb) Multiome | 450 | |
| chr19:51,002,137–51,003,245 | 279.5 kb | Distal (>10kb) Multiome | 304 | |
| chr19:51,016,816–51,017,391 | 293.7 kb | Distal (>10kb) Multiome | 394 |
Genomic view of the CLEC11A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.