The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for CLDN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLDN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLDN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:73,556,852–73,558,145 | 273.6 kb | Distal (>10kb) Multiome | 1080 | |
| chr7:73,578,111–73,579,357 | 252.2 kb | Distal (>10kb) Multiome | 765 | |
| chr7:73,622,785–73,623,555 | 207.9 kb | Distal (>10kb) Multiome | 659 | |
| chr7:73,623,956–73,624,915 | 206.4 kb | Distal (>10kb) Multiome | 652 | |
| chr7:73,647,765–73,648,318 | 183.0 kb | Distal (>10kb) Multiome | 506 | |
| chr7:73,667,449–73,668,409 | 163.2 kb | Distal (>10kb) Multiome | 678 | |
| chr7:73,682,807–73,684,039 | 147.5 kb | Distal (>10kb) Multiome | 803 | |
| chr7:73,703,674–73,704,431 | 126.9 kb | Distal (>10kb) Multiome | 226 | |
| chr7:73,719,255–73,720,191 | 111.3 kb | Distal (>10kb) Multiome | 478 | |
| chr7:73,734,760–73,735,432 | 96.1 kb | Distal (>10kb) Multiome | 592 | |
| chr7:73,738,048–73,739,612 | 92.0 kb | Distal (>10kb) Multiome | 949 | |
| chr7:73,741,460–73,743,811 | 88.0 kb | Distal (>10kb) Multiome | 604 | |
| chr7:73,769,598–73,771,029 | 60.5 kb | Distal (>10kb) Multiome | 496 | |
| chr7:73,830,827–73,831,245 | at TSS | At TSS | 444 | |
| chr7:73,831,659–73,832,518 | 1.3 kb | Proximal (<10kb) Multiome | 447 | |
| chr7:73,841,730–73,843,136 | 11.5 kb | Distal (>10kb) Multiome | 575 | |
| chr7:74,026,698–74,027,309 | 196.0 kb | Distal (>10kb) Multiome | 294 | |
| chr7:74,067,853–74,068,319 | 237.0 kb | Distal (>10kb) Multiome | 359 | |
| chr7:74,082,928–74,085,020 | 252.7 kb | Distal (>10kb) Multiome | 602 | |
| chr7:74,094,257–74,095,257 | 263.9 kb | Distal (>10kb) Multiome | 409 |
Genomic view of the CLDN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.