Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; focal adhesion; and microtubule cytoskeleton. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CLASP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLASP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLASP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:33,425,913–33,426,646 | 219.2 kb | Distal (>10kb) Multiome | 224 | |
| chr3:33,439,404–33,441,603 | 204.9 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:33,446,268–33,447,578 | 198.9 kb | Distal (>10kb) Multiome | 160 | |
| chr3:33,645,426–33,645,576 | at TSS | At TSS | 95 | |
| chr3:33,658,997–33,659,827 | 13.8 kb | Distal (>10kb) Multiome | 599 | |
| chr3:33,717,274–33,718,580 | 72.7 kb | Distal (>10kb) Multiome | 885 | |
| chr3:33,787,069–33,787,693 | 142.0 kb | Distal (>10kb) Multiome | 311 | |
| chr3:33,798,073–33,799,435 | 153.4 kb | Distal (>10kb) Multiome | 1044 | |
| chr3:34,013,702–34,014,461 | 368.6 kb | Distal (>10kb) Multiome | 155 |
Genomic view of the CLASP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.