The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CKB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CKB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CKB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:103,333,053–103,335,386 | 188.7 kb | Distal (>10kb) Multiome | 1004 | |
| chr14:103,384,755–103,386,021 | 137.5 kb | Distal (>10kb) Multiome | 863 | |
| chr14:103,456,058–103,456,564 | 66.5 kb | Distal (>10kb) Multiome | 49 | |
| chr14:103,518,427–103,519,043 | 4.0 kb | Proximal (<10kb) Multiome | 404 | |
| chr14:103,520,443–103,523,552 | 33 bp | At TSS Multiome | 756 | |
| chr14:103,528,671–103,529,619 | 6.3 kb | Proximal (<10kb) Multiome | 726 | |
| chr14:103,561,982–103,563,356 | 40.0 kb | Distal (>10kb) Multiome | 781 | |
| chr14:103,628,110–103,630,126 | 106.3 kb | Distal (>10kb) Multiome | 909 | |
| chr14:103,715,029–103,716,504 | 192.8 kb | Distal (>10kb) Multiome | 709 |
Genomic view of the CKB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.