Enables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CKAP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CKAP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CKAP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:105,235,605–105,236,419 | 1012.0 kb | Distal (>10kb) Multiome HiCAR | 802 | |
| chr12:105,986,583–105,987,623 | 260.9 kb | Distal (>10kb) Multiome | 272 | |
| chr12:106,138,295–106,140,144 | 108.9 kb | Distal (>10kb) Multiome | 675 | |
| chr12:106,247,023–106,248,967 | 123 bp | At TSS Multiome | 593 | |
| chr12:106,254,770–106,255,094 | 6.8 kb | Proximal (<10kb) | 93 | |
| chr12:106,301,702–106,303,676 | 55.5 kb | Distal (>10kb) Multiome | 881 | |
| chr12:106,357,226–106,358,686 | 109.9 kb | Distal (>10kb) Multiome | 1122 | |
| chr12:106,954,854–106,956,979 | 707.7 kb | Distal (>10kb) Multiome HiCAR | 927 |
Genomic view of the CKAP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.