The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for CIZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CIZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CIZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,897,316–127,897,796 | 294.1 kb | Distal (>10kb) Multiome | 437 | |
| chr9:127,898,861–127,900,094 | 292.0 kb | Distal (>10kb) Multiome | 630 | |
| chr9:127,916,386–127,917,505 | 274.5 kb | Distal (>10kb) Multiome | 474 | |
| chr9:127,926,756–127,928,574 | 264.1 kb | Distal (>10kb) Multiome | 411 | |
| chr9:127,930,321–127,931,068 | 260.8 kb | Distal (>10kb) Multiome | 537 | |
| chr9:127,937,578–127,938,244 | 253.7 kb | Distal (>10kb) Multiome | 674 | |
| chr9:127,955,445–127,955,915 | 236.0 kb | Distal (>10kb) Multiome | 540 | |
| chr9:127,980,172–127,981,966 | 210.5 kb | Distal (>10kb) Multiome | 691 | |
| chr9:128,033,544–128,034,106 | 157.7 kb | Distal (>10kb) Multiome | 69 | |
| chr9:128,034,940–128,035,527 | 156.2 kb | Distal (>10kb) Multiome | 480 | |
| chr9:128,066,577–128,068,774 | 124.2 kb | Distal (>10kb) Multiome | 874 | |
| chr9:128,097,872–128,098,910 | 93.2 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 73.7 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 63.3 kb | Distal (>10kb) Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 31.5 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,181,549–128,181,741 | 9.8 kb | Proximal (<10kb) | 33 | |
| chr9:128,191,300–128,192,050 | 71 bp | At TSS Multiome | 865 | |
| chr9:128,203,004–128,204,704 | 12.8 kb | Distal (>10kb) Multiome | 690 | |
| chr9:128,218,656–128,219,107 | 27.3 kb | Distal (>10kb) Multiome | 410 | |
| chr9:128,250,012–128,251,099 | 59.0 kb | Distal (>10kb) Multiome | 353 | |
| chr9:128,275,636–128,276,535 | 84.5 kb | Distal (>10kb) Multiome | 728 | |
| chr9:128,322,183–128,322,933 | 131.0 kb | Distal (>10kb) Multiome | 962 | |
| chr9:128,340,070–128,341,161 | 148.9 kb | Distal (>10kb) Multiome | 803 | |
| chr9:128,364,858–128,365,437 | 173.5 kb | Distal (>10kb) Multiome | 442 | |
| chr9:128,420,259–128,421,260 | 229.1 kb | Distal (>10kb) Multiome | 701 | |
| chr9:128,455,721–128,456,522 | 264.5 kb | Distal (>10kb) Multiome | 684 | |
| chr9:130,171,788–130,172,513 | 1980.7 kb | Distal (>10kb) Multiome HiCAR | 253 |
Genomic view of the CIZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.