The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for CITED2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CITED2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CITED2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:139,134,756–139,136,229 | 239.6 kb | Distal (>10kb) Multiome | 714 | |
| chr6:139,219,088–139,219,883 | 155.2 kb | Distal (>10kb) Multiome | 525 | |
| chr6:139,313,822–139,314,248 | 60.7 kb | Distal (>10kb) Multiome | 100 | |
| chr6:139,364,486–139,364,674 | 10.0 kb | Proximal (<10kb) | 153 | |
| chr6:139,367,489–139,368,506 | 6.6 kb | Proximal (<10kb) Multiome | 208 | |
| chr6:139,368,709–139,370,608 | 4.0 kb | Proximal (<10kb) | 542 | |
| chr6:139,372,852–139,376,242 | 840 bp | At TSS Multiome | 1354 | |
| chr6:139,376,704–139,376,828 | 2.1 kb | Proximal (<10kb) | 268 | |
| chr6:139,534,066–139,535,422 | 160.0 kb | Distal (>10kb) Multiome HiCAR | 425 | |
| chr6:139,587,515–139,588,861 | 213.7 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr6:139,888,440–139,889,371 | 514.3 kb | Distal (>10kb) Multiome HiCAR | 257 |
Genomic view of the CITED2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.