Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CIR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CIR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CIR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:174,247,891–174,249,190 | 147.1 kb | Distal (>10kb) Multiome | 1036 | |
| chr2:174,333,695–174,335,223 | 60.8 kb | Distal (>10kb) Multiome | 488 | |
| chr2:174,335,637–174,337,967 | 58.7 kb | Distal (>10kb) Multiome | 695 | |
| chr2:174,395,360–174,396,472 | 64 bp | At TSS Multiome | 847 | |
| chr2:174,486,155–174,487,807 | 91.5 kb | Distal (>10kb) Multiome | 793 | |
| chr2:174,681,628–174,683,737 | 287.2 kb | Distal (>10kb) Multiome | 464 |
Genomic view of the CIR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.