The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for CINP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CINP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CINP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:102,086,286–102,088,835 | 275.7 kb | Distal (>10kb) Multiome | 1052 | |
| chr14:102,097,398–102,098,067 | 265.2 kb | Distal (>10kb) Multiome | 159 | |
| chr14:102,139,026–102,140,960 | 223.2 kb | Distal (>10kb) Multiome | 844 | |
| chr14:102,247,845–102,248,746 | 114.5 kb | Distal (>10kb) Multiome | 142 | |
| chr14:102,304,511–102,305,687 | 57.7 kb | Distal (>10kb) Multiome | 568 | |
| chr14:102,314,028–102,314,685 | 48.5 kb | Distal (>10kb) Multiome | 720 | |
| chr14:102,316,590–102,317,741 | 45.7 kb | Distal (>10kb) Multiome | 885 | |
| chr14:102,319,368–102,320,458 | 43.1 kb | Distal (>10kb) Multiome | 675 | |
| chr14:102,362,620–102,363,583 | 130 bp | At TSS Multiome | 705 | |
| chr14:102,507,117–102,508,097 | 144.8 kb | Distal (>10kb) Multiome | 100 | |
| chr14:102,508,416–102,511,398 | 147.0 kb | Distal (>10kb) Multiome | 778 | |
| chr14:102,516,500–102,517,914 | 154.1 kb | Distal (>10kb) Multiome | 694 | |
| chr14:102,524,045–102,525,126 | 161.9 kb | Distal (>10kb) Multiome | 817 | |
| chr14:102,545,130–102,546,123 | 182.9 kb | Distal (>10kb) Multiome | 458 | |
| chr14:102,554,738–102,555,873 | 192.7 kb | Distal (>10kb) Multiome | 280 | |
| chr14:102,585,306–102,585,775 | 222.7 kb | Distal (>10kb) Multiome | 259 | |
| chr14:102,591,431–102,593,846 | 229.6 kb | Distal (>10kb) Multiome | 895 |
Genomic view of the CINP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.