This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Transcription factors with Perturb-seq knockdown data for CIB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CIB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CIB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:89,999,673–90,000,089 | 234.0 kb | Distal (>10kb) Multiome | 174 | |
| chr15:90,001,237–90,002,666 | 232.2 kb | Distal (>10kb) Multiome | 589 | |
| chr15:90,059,488–90,060,208 | 174.1 kb | Distal (>10kb) Multiome | 439 | |
| chr15:90,061,829–90,062,285 | 171.8 kb | Distal (>10kb) Multiome | 347 | |
| chr15:90,075,459–90,076,479 | 158.0 kb | Distal (>10kb) Multiome | 275 | |
| chr15:90,101,730–90,103,001 | 131.4 kb | Distal (>10kb) Multiome | 693 | |
| chr15:90,143,210–90,143,683 | 90.6 kb | Distal (>10kb) Multiome | 578 | |
| chr15:90,152,072–90,152,533 | 81.6 kb | Distal (>10kb) Multiome HiCAR | 92 | |
| chr15:90,157,949–90,158,473 | 75.8 kb | Distal (>10kb) Multiome HiCAR | 670 | |
| chr15:90,184,585–90,185,456 | 48.9 kb | Distal (>10kb) Multiome | 806 | |
| chr15:90,200,589–90,202,277 | 32.7 kb | Distal (>10kb) Multiome | 649 | |
| chr15:90,233,136–90,234,524 | 84 bp | At TSS Multiome | 900 | |
| chr15:90,249,345–90,249,851 | 15.6 kb | Distal (>10kb) Multiome | 655 | |
| chr15:90,265,146–90,266,455 | 31.7 kb | Distal (>10kb) Multiome | 956 | |
| chr15:90,293,225–90,293,932 | 59.6 kb | Distal (>10kb) Multiome | 251 | |
| chr15:90,301,063–90,301,545 | 67.4 kb | Distal (>10kb) Multiome | 241 | |
| chr15:90,319,899–90,320,433 | 86.3 kb | Distal (>10kb) Multiome | 503 | |
| chr15:90,351,610–90,352,876 | 118.3 kb | Distal (>10kb) Multiome | 679 | |
| chr15:90,387,660–90,388,880 | 154.2 kb | Distal (>10kb) Multiome | 722 | |
| chr15:90,529,290–90,530,702 | 296.0 kb | Distal (>10kb) Multiome | 627 |
Genomic view of the CIB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.