This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CHST2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHST2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHST2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:142,863,026–142,863,734 | 256.5 kb | Distal (>10kb) Multiome | 186 | |
| chr3:142,866,818–142,867,310 | 252.7 kb | Distal (>10kb) Multiome | 187 | |
| chr3:142,888,221–142,889,512 | 231.0 kb | Distal (>10kb) Multiome | 691 | |
| chr3:142,962,519–142,964,437 | 155.9 kb | Distal (>10kb) Multiome | 781 | |
| chr3:143,000,964–143,002,299 | 118.3 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:143,117,090–143,117,409 | 2.4 kb | Proximal (<10kb) | 7 | |
| chr3:143,118,976–143,122,095 | 82 bp | At TSS Multiome | 740 |
Genomic view of the CHST2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.