This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for CHST10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHST10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHST10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:100,118,833–100,120,020 | 297.9 kb | Distal (>10kb) Multiome | 136 | |
| chr2:100,321,138–100,322,670 | 95.8 kb | Distal (>10kb) Multiome | 420 | |
| chr2:100,408,211–100,408,487 | 8.9 kb | Proximal (<10kb) | 3 | |
| chr2:100,416,735–100,417,903 | 172 bp | At TSS Multiome | 713 | |
| chr2:100,422,416–100,422,616 | 5.0 kb | Proximal (<10kb) | 54 | |
| chr2:100,561,925–100,563,639 | 145.6 kb | Distal (>10kb) Multiome | 976 | |
| chr2:100,639,460–100,640,170 | 222.4 kb | Distal (>10kb) Multiome | 46 |
Genomic view of the CHST10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.