The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for CHRNA5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHRNA5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHRNA5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:78,299,130–78,299,874 | 265.9 kb | Distal (>10kb) Multiome | 798 | |
| chr15:78,303,744–78,304,214 | 261.7 kb | Distal (>10kb) Multiome | 287 | |
| chr15:78,340,100–78,340,745 | 225.3 kb | Distal (>10kb) Multiome | 194 | |
| chr15:78,348,106–78,348,824 | 217.1 kb | Distal (>10kb) Multiome | 178 | |
| chr15:78,437,554–78,438,897 | 127.4 kb | Distal (>10kb) Multiome | 918 | |
| chr15:78,506,965–78,508,087 | 58.1 kb | Distal (>10kb) Multiome | 674 | |
| chr15:78,539,941–78,541,020 | 25.1 kb | Distal (>10kb) Multiome | 773 | |
| chr15:78,564,790–78,566,388 | 73 bp | At TSS Multiome | 618 | |
| chr15:78,619,950–78,621,461 | 54.6 kb | Distal (>10kb) Multiome | 274 | |
| chr15:78,640,579–78,641,869 | 75.8 kb | Distal (>10kb) Multiome | 406 | |
| chr15:78,671,569–78,672,301 | 106.3 kb | Distal (>10kb) Multiome | 254 | |
| chr15:78,810,245–78,812,147 | 246.0 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the CHRNA5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.