Enables diacylglycerol cholinephosphotransferase activity. Involved in phosphatidylcholine biosynthetic process and platelet activating factor biosynthetic process. Is active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CHPT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHPT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHPT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:101,406,958–101,408,760 | 289.8 kb | Distal (>10kb) Multiome | 896 | |
| chr12:101,696,663–101,698,677 | 66 bp | At TSS Multiome | 939 | |
| chr12:101,698,797–101,698,945 | 1.2 kb | Proximal (<10kb) | 169 | |
| chr12:101,703,526–101,703,762 | 5.9 kb | Proximal (<10kb) | 55 | |
| chr12:101,830,071–101,831,573 | 133.3 kb | Distal (>10kb) Multiome | 637 | |
| chr12:101,876,810–101,878,266 | 179.9 kb | Distal (>10kb) Multiome | 1007 |
Genomic view of the CHPT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.