This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for CHN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:28,853,800–28,854,705 | 292.3 kb | Distal (>10kb) Multiome | 539 | |
| chr7:28,955,385–28,958,976 | 189.8 kb | Distal (>10kb) Multiome | 922 | |
| chr7:29,042,753–29,043,889 | 103.3 kb | Distal (>10kb) Multiome | 153 | |
| chr7:29,119,376–29,120,071 | 26.8 kb | Distal (>10kb) Multiome | 66 | |
| chr7:29,128,296–29,129,278 | 17.6 kb | Distal (>10kb) Multiome | 36 | |
| chr7:29,146,054–29,146,726 | 70 bp | At TSS Multiome | 469 | |
| chr7:29,189,638–29,190,162 | 43.4 kb | Distal (>10kb) Multiome | 425 | |
| chr7:29,193,845–29,195,453 | 48.2 kb | Distal (>10kb) Multiome | 618 | |
| chr7:29,197,003–29,197,211 | 2.2 kb | Proximal (<10kb) | 25 |
Genomic view of the CHN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.