CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CHMP4C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHMP4C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHMP4C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:81,630,496–81,631,299 | 101.4 kb | Distal (>10kb) Multiome | 326 | |
| chr8:81,685,772–81,686,622 | 46.2 kb | Distal (>10kb) Multiome | 915 | |
| chr8:81,720,515–81,721,822 | 11.1 kb | Distal (>10kb) Multiome | 750 | |
| chr8:81,731,713–81,733,032 | 227 bp | At TSS Multiome | 732 | |
| chr8:81,895,652–81,897,396 | 163.7 kb | Distal (>10kb) Multiome | 316 | |
| chr8:81,897,889–81,899,280 | 165.8 kb | Distal (>10kb) Multiome | 138 | |
| chr8:81,903,428–81,904,466 | 171.4 kb | Distal (>10kb) Multiome | 155 | |
| chr8:81,912,367–81,913,089 | 180.3 kb | Distal (>10kb) Multiome | 113 |
Genomic view of the CHMP4C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.