CHMP2A

charged multivesicular body protein 2A | BC-2, CHMP2, VPS2, VPS2A

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Member of: DE-1 DE-1.49

Biological processes 82 terms

ESCRT III complex (GO:0000815)ESCRT III complex (GO:0000815)ESCRT III complex (GO:0000815)ESCRT III complex disassembly (GO:1904903)amphisome membrane (GO:1904930)amphisome membrane (GO:1904930)autophagosome maturation (GO:0097352)autophagosome maturation (GO:0097352)autophagosome membrane (GO:0000421)autophagy (GO:0006914)chromatin (GO:0000785)cytosol (GO:0005829)cytosol (GO:0005829)endosome transport via multivesicular body sorting pathway (GO:0032509)establishment of protein localization (GO:0045184)exit from mitosis (GO:0010458)extracellular exosome (GO:0070062)kinetochore (GO:0000776)kinetochore (GO:0000776)kinetochore microtubule (GO:0005828)kinetochore microtubule (GO:0005828)late endosome membrane (GO:0031902)late endosome to lysosome transport (GO:1902774)late endosome to lysosome transport (GO:1902774)late endosome to vacuole transport (GO:0045324)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)macroautophagy (GO:0016236)membrane (GO:0016020)membrane bending activity (GO:0180020)membrane coat (GO:0030117)membrane fission (GO:0090148)membrane fission (GO:0090148)membrane invagination (GO:0010324)midbody (GO:0030496)midbody (GO:0030496)midbody abscission (GO:0061952)midbody abscission (GO:0061952)mitotic metaphase chromosome alignment (GO:0007080)mitotic metaphase chromosome alignment (GO:0007080)multivesicular body (GO:0005771)multivesicular body assembly (GO:0036258)multivesicular body assembly (GO:0036258)multivesicular body membrane (GO:0032585)multivesicular body membrane (GO:0032585)multivesicular body sorting pathway (GO:0071985)multivesicular body sorting pathway (GO:0071985)multivesicular body-lysosome fusion (GO:0061763)negative regulation of centriole elongation (GO:1903723)nuclear envelope (GO:0005635)nuclear envelope (GO:0005635)nuclear membrane reassembly (GO:0031468)nuclear membrane reassembly (GO:0031468)nuclear pore (GO:0005643)nucleus organization (GO:0006997)phosphatidylcholine binding (GO:0031210)plasma membrane (GO:0005886)plasma membrane repair (GO:0001778)plasma membrane repair (GO:0001778)positive regulation of exosomal secretion (GO:1903543)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein homooligomerization (GO:0051260)protein polymerization (GO:0051258)protein transport (GO:0015031)regulation of centrosome duplication (GO:0010824)regulation of mitotic spindle assembly (GO:1901673)regulation of mitotic spindle assembly (GO:1901673)ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162)ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162)vacuolar transport (GO:0007034)vesicle fusion with vacuole (GO:0051469)viral budding from plasma membrane (GO:0046761)viral budding from plasma membrane (GO:0046761)viral budding from plasma membrane (GO:0046761)viral budding via host ESCRT complex (GO:0039702)viral budding via host ESCRT complex (GO:0039702)viral budding via host ESCRT complex (GO:0039702)viral budding via host ESCRT complex (GO:0039702)viral budding via host ESCRT complex (GO:0039702)viral release from host cell (GO:0019076)viral release from host cell (GO:0019076)

Expression (TPM)

TFs regulating CHMP2A 0 TFs

Transcription factors with Perturb-seq knockdown data for CHMP2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHMP2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CHMP2A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHMP2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:58,278,271–58,279,774	276.2 kb	Distal (>10kb) Multiome	950
chr19:58,304,887–58,305,868	249.7 kb	Distal (>10kb) Multiome	858
chr19:58,326,789–58,327,710	228.0 kb	Distal (>10kb) Multiome	985
chr19:58,347,086–58,347,987	207.4 kb	Distal (>10kb) Multiome	467
chr19:58,356,174–58,356,775	198.5 kb	Distal (>10kb) Multiome	101
chr19:58,361,859–58,363,243	192.2 kb	Distal (>10kb) Multiome	972
chr19:58,380,269–58,381,636	173.9 kb	Distal (>10kb) Multiome	1044
chr19:58,386,311–58,387,531	167.9 kb	Distal (>10kb) Multiome	1010
chr19:58,395,438–58,396,606	159.3 kb	Distal (>10kb) Multiome	448
chr19:58,400,803–58,401,800	153.6 kb	Distal (>10kb) Multiome	728
chr19:58,408,032–58,409,025	146.5 kb	Distal (>10kb) Multiome	854
chr19:58,451,175–58,452,075	103.5 kb	Distal (>10kb) Multiome	702
chr19:58,466,585–58,467,517	88.0 kb	Distal (>10kb) Multiome	701
chr19:58,475,442–58,476,812	79.0 kb	Distal (>10kb) Multiome	934
chr19:58,498,641–58,499,856	55.6 kb	Distal (>10kb) Multiome	939
chr19:58,513,642–58,514,431	40.9 kb	Distal (>10kb) Multiome	706
chr19:58,518,851–58,520,372	35.2 kb	Distal (>10kb) Multiome	1175
chr19:58,538,071–58,538,713	16.5 kb	Distal (>10kb) Multiome	386

Genome Browser

Genomic view of the CHMP2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.