Enables transmembrane transporter binding activity. Involved in positive regulation of calcineurin-NFAT signaling cascade and release of sequestered calcium ion into cytosol. Acts upstream of or within intracellular calcium ion homeostasis and negative regulation of cell population proliferation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CHERP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHERP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHERP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:16,247,463–16,247,928 | 294.6 kb | Distal (>10kb) Multiome | 370 | |
| chr19:16,324,466–16,326,401 | 216.3 kb | Distal (>10kb) Multiome | 477 | |
| chr19:16,471,332–16,472,638 | 70.3 kb | Distal (>10kb) Multiome | 645 | |
| chr19:16,495,870–16,496,694 | 46.1 kb | Distal (>10kb) Multiome | 780 | |
| chr19:16,541,995–16,543,080 | 106 bp | At TSS Multiome | 880 | |
| chr19:16,571,833–16,572,764 | 30.1 kb | Distal (>10kb) Multiome | 814 | |
| chr19:16,627,176–16,629,209 | 86.0 kb | Distal (>10kb) Multiome | 896 | |
| chr19:16,659,555–16,661,823 | 117.7 kb | Distal (>10kb) Multiome | 987 | |
| chr19:16,828,911–16,830,011 | 287.0 kb | Distal (>10kb) Multiome | 623 |
Genomic view of the CHERP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.