Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and DNA helicase activity. Predicted to be involved in chromatin organization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CHD9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHD9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHD9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:53,043,558–53,045,930 | 9.7 kb | Proximal (<10kb) Multiome | 355 | |
| chr16:53,052,587–53,053,481 | 1.6 kb | Proximal (<10kb) | 442 | |
| chr16:53,054,431–53,055,995 | 21 bp | At TSS Multiome | 1030 | |
| chr16:53,098,844–53,100,248 | 44.7 kb | Distal (>10kb) Multiome | 981 | |
| chr16:53,129,893–53,132,047 | 75.7 kb | Distal (>10kb) Multiome | 941 | |
| chr16:53,207,832–53,208,752 | 153.3 kb | Distal (>10kb) Multiome | 483 | |
| chr16:53,433,981–53,435,683 | 379.5 kb | Distal (>10kb) Multiome | 929 | |
| chr16:53,502,382–53,504,919 | 448.4 kb | Distal (>10kb) Multiome | 983 |
Genomic view of the CHD9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.